Positive frequency dependent selection is a natural selection regime where the fitness of a phenotype increases with its frequency in the population. Examples can be typically found in the spread of disease tolerance strategies in a population. A characterizing feature of PFDS is that the focal allele may experience favorable selection only when it becomes more frequent in the population, while being selected against when it is rare. In this paper, by applying a solution concept from evolutionary game theory, we (...) hypothesize that the process of emergence of such alleles triggers selection for silence, where the emergence of alleles that can stay unexpressed for a period of time will be favored by selection forces. We illustrate our hypothesis using a mathematical model of a population of single locus diploid organisms with two alleles where a single mutant of an allele that experiences positive frequency dependent selection appears in a population where the other allele is a dominant. The model results show that the longer the silence interval of the new mutant before its expression, the better its chances of getting fixed in the population. However, this effect will be observable only to a certain limit after which further increase in the interval will not have an effect on the expected fixation rate. Two divergences from the simple scenario are also investigated: the nonsynchronous expression of the focal allele and its emergence in a spatial grid limited by a migration bottleneck. In all cases, it is shown that there is an evolutionary pressure inherent in the dynamics of positive frequency dependent selection on the genes to have a delayed expression. It is hypothesized that the regulation systems of such traits will be under selection for either internal silencing mechanisms or to be triggered by an external environmental condition. (shrink)

“Para que isso servirá em minha vida?” Ao longo de minha trajetória como professor do ensino secundário, ouvi esta pergunta algumas vezes. É provável que nós professores de filosofia não sejamos um alvo privilegiado dessa pergunta provocadora. Trata-se mesmo de uma questão legítima, ainda mais para nós: latinoamericanos, brasileiros, nordestinos, piauienses. Trata-se de uma pergunta que evoca um certo desespero, uma certa pressa, um tipo de agonia que é bem nossa; como quando dizemos “estou agoniado”. Queremos tudo “pra já”. Parece (...) que jamais nos daremos o direito de viver e aprender algo pelo simples fato de que o saber é bom e merece ser fruído. (shrink)

This work has two objectives. The first is to begin a mathematical formalism appropriate to treating particles which only interact with each otherindirectly due to hypothesized memory effects in a stochastic medium. More specifically we treat a situation in which a sequence of particles consecutively passes through a region (e.g., a measuring apparatus) in such a way that one particle leaves the region before the next one enters. We want to study a situation in which a particle may interact with (...) other particles that previously passed through the system via disturbances made in the region by these previous particles.Second, we apply the type of stochastic process appearing in this context to the stochastic interpretation of quantum mechanics to obtain a modified version of this interpretation. This version is free of many of the criticisms made against the stochastic interpretation of quantum mechanics. (shrink)

The theory of chemical symbiosis suggests that biological systems started with the collaboration of two polymeric molecules existing in early Earth: nucleic acids and peptides. Chemical symbiosis emerged when RNA-like nucleic acid polymers happened to fold into 3D structures capable to bind amino acids together, forming a proto peptidyl-transferase center. This folding catalyzed the formation of quasi-random small peptides, some of them capable to bind this ribozyme structure back and starting to form an initial layer that would produce the larger (...) subunit of the ribosome by accretion. TCS suggests that there is no chicken-and-egg problem into the emergence of biological systems as RNAs and peptides were of equal importance to the origin of life. Life has initially emerged when these two macromolecules started to interact in molecular symbiosis. Further, we suggest that life evolved into progenotes and cells due to the emergence of new layers of symbiosis. Mutualism is the strongest force in biology, capable to create novelties by emergent principles; on which the whole is bigger than the sum of the parts. TCS aims to apply the Margulian view of biology into the origins of life field. (shrink)

Many students feel despair when addressing systemic issues of ethical significance, such as climate change, and student despair has been exacerbated by the circumstances of the Covid-19 pandemic. This creates an unwelcoming space for authentic student engagement. To address the problem, we present an imaginary of radical hope, a pedagogical tool informed by trauma, for developing a brave space for class discussion. It is psychologically beneficial to acknowledge negative emotions, clearing the emotional space for students to engage. Therefore, we frame (...) ethics courses with an uncomfortable discussion, asking students to draw from their positionality and share their feelings of hope and despair, related to course material. In this paper, we explain the problem of despair motivating the project, describe the pedagogical and ethical support of our strategy, share the assignment, activity, and examples, and discuss takeaways. (shrink)

Este trabalho se propõe a apresentar o tema da compaixão em Schopenhauer e o da solidariedade em Rorty a partir da perspectiva filosófica de cada um dos pensadores. Não pretendemos aprofundar o problema em quaisquer das perspectivas, seja a metafísica ou a neopragmatista, mas apenas mostrar como a perspectiva de cada filósofo leva a uma concepção, ao menos aparentemente, diferente sobre um problema comum.

Most people assume that criminal offenders have only been convicted of a single crime. However, in reality almost half of offenders stand to be sentenced for more than one crime. The high proportion of multiple crime offenders poses a number of practical and theoretical challenges for the criminal justice system. For instance, how should courts punish multiple offenders relative to individuals who have been sentenced for a single crime? How should they be punished relative to each other? Sentencing Multiple Crimes (...) discusses these questions from the perspective of several legal theories. This volume considers questions such as the proportionality of the crimes committed, the temporal span between the crimes, and the relationship between theories about the punitive treatment of recidivists and multiple offenders. Contributors from around the world and in the fields of legal theory, philosophy, and psychology offer their perspectives to the volume. A comprehensive examination of the dynamics involved with sentencing multiple offenders has the potential to be a powerful tool for legal scholars and professionals, particularly given the practical importance of the topic and the relative dearth of research about punishment of multiple offense cases. (shrink)

Afshar et al. claim that their experiment shows a violation of the complementarity inequality. In this work, we study their claim using a modified Mach-Zehnder setup that represents a simpler version of the Afshar experiment. We find that our results are consistent with Afshar et al. experimental findings. However, we show that within standard quantum mechanics the results of the Afshar experiment do not lead to a violation of the complementarity inequality. We show that their claim originates from a particular (...) technique they use to analyze their results. In their analysis, they assume a classical concept, that particles have a definite trajectory before detection, thus, they obtain which-way information by particle detection plus path extrapolation by applying momentum conservation. This analysis technique is standard in experimental particle physics. Important discoveries such as the detection of vector bosons have been made through the application of this technique. We note that particle detection plus path extrapolation is a suitable technique within de Broglie-Bohm theory of quantum mechanics. (shrink)

Unfounded—conspiracy and health—beliefs about COVID-19 have accompanied the pandemic worldwide. Here, we examined cross-nationally the structure and correlates of these beliefs with an 8-item scale, using a multigroup confirmatory factor analysis. We obtained a two-factor model of unfounded (conspiracy and health) beliefs with good internal structure (average CFI = 0.98, RMSEA = 0.05, SRMR = 0.04), but a high correlation between the two factors (average latent factor correlation = 0.57). This model was replicable across 50 countries (total N = 13,579), (...) as evidenced by metric invariance between countries (CFI = 0.96, RMSEA = 0.06, SRMS = 0.07) as well as scalar invariance across genders (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03) and educational levels (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03). Also, lower levels of education, more fear of COVID-19, and more cynicism were weakly associated with stronger conspiracy and health beliefs. The study contributes to knowledge about the structure of unfounded beliefs, and reveals the potential relevance of affective (i.e., fear of COVID-19) and cognitive (i.e., cynicism) factors along with demographics, in endorsing such beliefs. In summary, we obtained cross-cultural evidence for the distinctiveness of unfounded conspiracy and health beliefs about COVID-19 in terms of their structure and correlates. (shrink)

Unfounded—conspiracy and health—beliefs about COVID-19 have accompanied the pandemic worldwide. Here, we examined cross-nationally the structure and correlates of these beliefs with an 8-item scale, using a multigroup confirmatory factor analysis. We obtained a two-factor model of unfounded (conspiracy and health) beliefs with good internal structure (average CFI = 0.98, RMSEA = 0.05, SRMR = 0.04), but a high correlation between the two factors (average latent factor correlation = 0.57). This model was replicable across 50 countries (total N = 13,579), (...) as evidenced by metric invariance between countries (CFI = 0.96, RMSEA = 0.06, SRMS = 0.07) as well as scalar invariance across genders (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03) and educational levels (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03). Also, lower levels of education, more fear of COVID-19, and more cynicism were weakly associated with stronger conspiracy and health beliefs. The study contributes to knowledge about the structure of unfounded beliefs, and reveals the potential relevance of affective (i.e., fear of COVID-19) and cognitive (i.e., cynicism) factors along with demographics, in endorsing such beliefs. In summary, we obtained cross-cultural evidence for the distinctiveness of unfounded conspiracy and health beliefs about COVID-19 in terms of their structure and correlates. (shrink)

The extent to which game play is experienced as engaging is an important criterion for the playability of video games. This study investigates how video games can be designed towards increased levels of experienced engagement over time. For this purpose, two experiments were conducted in which a total of 35 participants repeatedly played a video game. Results indicate that experienced engagement is based on the extent to which the game provides rich experiences as well as by the extent to which (...) the game provides a sense of control. In view of the influence of both game features and players’ expertise on the levels of experienced richness and control, it is concluded that game features should be modified over time to maintain optimal levels of engagement. (shrink)

For an arbitrary similarity type of Boolean Algebras with Operators we define a class ofSahlqvist identities. Sahlqvist identities have two important properties. First, a Sahlqvist identity is valid in a complex algebra if and only if the underlying relational atom structure satisfies a first-order condition which can be effectively read off from the syntactic form of the identity. Second, and as a consequence of the first property, Sahlqvist identities arecanonical, that is, their validity is preserved under taking canonical embedding algebras. (...) Taken together, these properties imply that results about a Sahlqvist variety V van be obtained by reasoning in the elementary class of canonical structures of algebras in V.We give an example of this strategy in the variety of Cylindric Algebras: we show that an important identity calledHenkin's equation is equivalent to a simpler identity that uses only one variable. We give a conceptually simple proof by showing that the first-order correspondents of these two equations are equivalent over the class of cylindric atom structures. (shrink)

This article provides ethical guidance on using race in health research as a variable or in defining the study population. To this end, a plain, non-exhaustive checklist is provided for researchers and research ethics committees, preceded by a brief introduction on the need for justification when using race as a variable or in defining a study population, the problem of exoticism, that distinctions pertain between race, ethnicity and ancestry, the problematic naming of races, and that race does not serve well (...) as a presumed biological construct in genetic research. (shrink)

Intercultural encounters generally imply dynamics of elaboration of symbolic universes by the social groups affected. Imperial domination of Asia, from the 18 th to the 20 th century, furthered the reinterpretation of existing symbolic universes, such as religious communities, as well as the creation of new modes of symbolic organization of social life, as national communities. This paper analyzes the construction of a religious-nationalist symbolic universe in a context strongly influenced by otherness. We consider the discourse on Hindu nation and (...) its Muslim other, by V.D. Savarkar, a Hindu nationalist ideologue that was written in the early decades of the 20 th century. We adopt phenomenology as theoretical framework and undertake content analysis of a primary source – Hindutva: Who is a Hindu? We argue that the Hindu nationalist ideologue elaborated a rhetoric of annihilation, in which the other of Hindu nation, the Muslim, is depicted as inferior through a double strategy: selective exaggeration of characteristics attributed to the Muslim; transfer of socially negative definitions to the other. (shrink)

Cadernos Zygmunt Bauman – C-ZB se estabelece como um periódico que tem por objetivo discutir com clareza e sinceridade as questões humanas a partir da visão do sociólogo polonês Zygmunt Bauman. Em sua primeira Edição v. 1, n. 1 (2011) o C-ZB aborda três pontos de grande importância. O primeiro artigo: “A História estilhaçada: tradições e usos do passado no diálogo entre Zygmunt Bauman e Hannah Arendt”. Outro momento pode ser apreciado com a leitura do artigo “O individualismo como estratégia (...) de cuidado de si na sociedade de consumo”. E finalmente todos poderão conferir no artigo “Consumismo como fuga simbólica do real”. Cadernos Zygmunt Bauman - C-ZB establishes itself as a journal that aims to discuss with clarity and sincerity human affairs from the perspective of Polish sociologist Zygmunt Bauman. In its first edition v. 1, n. 1 (2011) C-ZB addresses three points of great importance. The first article, "The History shattered: traditions and customs of the past in the dialogue between Zygmunt Bauman and Hannah Arendt. " Another moment is apparent from reading the article "Individualism as a strategy for self care in a consumer society. " And finally everyone to check the article "Consumerism as a symbolic escape from reality. ". (shrink)

Legislation on Disability/ Functional Diversity in Spain has experimented a great advance since 1982 to 2013, leaving the initial orientation, based on care and rehabilitation, toward another one based on rights and social inclusion as main objectives. However, this legislation has not been effective because in the same lap of time another transformation made it useless: the suppression of social rights that came from Keynesian politics and the progressive neoliberal ideology implantation. The evolution of People with Disability/ Functional Diversity labour (...) situation illustrates the imposition of what we name neoliberal “ableisment” over PFD labour rights. (shrink)

Arquivo integral da edição dos 25 anos de IFEN.

Cercetarea dupa tema si gen-calitate a literaturii bibliologice romanest pt. anii 1990 - 1997.

Neurosteroid 17 beta-estradiol (E2) is a steroid synthesized de novo in the nervous system that might influence neuronal activity and behavior. Nevertheless, the impact of E2 on the functioning of those neural systems in which it is slightly synthesized is less questioned. The vestibulo-ocular reflex (VOR) adaptation, may provide an ideal arena for investigating this issue. Indeed, E2 modulates cerebellar parallel fiber-Purkinje cell synaptic plasticity that underlies encoding of VOR adaptation. Moreover, aromatase expression in the cerebellum of adult rodents is (...) maintained at very low levels and localized to Purkinje cells. The significance of age-related maintenance of low levels of aromatase expression in the cerebellum on behavior, however, has yet to be explored. Our aim in this study was to determine whether E2 synthesis exerts an effective and persistent modulation of VOR adaptation in adult male rats. To answer this question, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in VOR adaptation using an oral dose (2.5 mg/kg) of the aromatase inhibitor Letrozole in peri-pubertal and post-pubertal male rats. We found that Letrozole acutely impaired gain increases and decreases in VOR adaptation without altering basal ocular-motor performance and that these effects were similar in peri-pubertal and post-pubertal rats. Thus, in adult male rats neurosteroid E2 effectively modulates VOR adaptation in both of the periods studied. These findings imply that the adult cerebellum uses E2 synthesis for modulating motor memory formation and suggest that low and extremely localized E2 production may play a role in adaptive phenomena. (shrink)